Origin of acetyl strophanthidin-induced ventricular arrhythmias.
نویسندگان
چکیده
منابع مشابه
Origin of acetyl strophanthidin-induced ventricular arrhythmias.
To examine the origin of digitalis-induced ventricular tachycardia (VT), acetyl strophanthidin (AS) (25 mug/min) was perfused into a limited zone of myocardium in intact anesthetized dogs through a catheter placed fluoroscopically in the left anterior descending artery without ischemia. A second catheter in the great cardiac vein sampled venous effluent from this region. His and left bundle bra...
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sponse to additionally added digitalis, and relation of antibody effects on digitalis-induced automaticity and contracture to reversal of inotropy. Specific antibody (but not control antibody) in 1.1-1.5-fold molar excess over cardioactive steroid concentrations blocked positive inotropic effects of ouabain and acetyl strophanthidin, and gradually reversed established contractile effects of the...
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Athletic performance tests the limits of the human body and mind. Awe-inspiring achievements is what makes sports so fascinating. It is well appreciated however that top-level sports may sometimes overtax the body, and can lead to injuries, most notably of musculo-skeletal nature. This paper defends the thesis that the heart can also develop sports injuries at the ventricular level. We will ela...
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The determination of the state of digitalization in a given patient is often difficult and at times impossible. Although Eggleston1 indicated that the required quantity of digitalis is a function of body weight, the digitalizing dose is an empiric and occasionally a dangerous assumption. Clinically, the classical symptoms of digitalis intoxication may mimic those of circulatory failure. Nausea,...
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The pharmacokinetics of acetyl strophanthidin (AS) were studied in dogs and human subjects by the use of a newly developed radioimmunoassay. This method has a sensitivity of 0.1 ng of AS per ml and is applicable to direct measurement of AS in unextracted plasma, urine, or bile. After administration of a single intravenous (i.v.) dose of 1.0 mg of AS to 17-25-kg mongrel dogs, the principal expon...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 1977
ISSN: 0021-9738
DOI: 10.1172/jci108629